WTF
That's confusing, but I can assure you it's nothing to do with me!
I'm guessing the Wacom tablet uses an API called Accessibility in macOS in order for it to work, and this is some new security measure because it means you're granting access for the whole UI to be controlled by another process - Wacom tablet driver in this case.
As far as the original keychain problem is concerned, I'm not sure what to say but for sure there definitely appears to be a problem with Sierra for you rather than with the app itself, although I don't have any similar reports and I can't repeat it myself either. That said, Sierra even had several GM versions before it went to release so it wouldn't surprise me if there were still lingering bugs although why it would only my app is a mystery right now.
I will make enquiries in developer circles. In the mean time, let me know if you find any magic cure